The "Give Me Everything" singer and rapper (real name: Armando Christian Perez) will also perform “No Doubt About It” alongside Jussie Smollett, who plays singer and newly installed Empire Records head Jamal Lyon.
Pitbull joins a long and impressive list of musical talent set to appear, including Alicia Keys, Lenny Kravitz, Ne-Yo, Kelly Rowland and Ludacris. On Wednesday, co-creator Lee Daniels revealed that Mariah Carey will guest this season. However, the deal is not yet in place.
The second season of Empire premieres on Sept. 23 at 9 p.m. on Fox.